The site of action of Strobilurin compounds is located in the mitochondrial respiration pathway as a result of this mode of action, Trifloxystrobin is a potent inhibitor of fungal spore germination and mycelial growth. Target Site of Action If available the biochemical mode of action is given. All of the co-solvents are provided by MCE. EXPOSURE: Workers that use trifloxystrobin may breathe in mists or have direct skin contact. It is harmless to predators of mites and suiable for use in IPM programs. Group 11 fungicide, 21. 0 The combination formulation of trifloxystrobin and tebuconazole (Nativo 75 WG)has broad spectrum activity, new mode of action and effective against major diseases of tomato in India. 2017 Jan;36(1):182-189. Single-site mode of action; resistance may occur. The site of action of strobilurin compounds is located in the mitochondrial respiration pathway. Trifloxystrobin (CGA 279202) is a fungicide, with EC50s of 23.0 μg/L and 1.7 μg/L for Daphnia magna neonate and embryos, respectively, after treatment for 48 h. - Mechanism of Action & Protocol. 2017 Jan;36(1):182-189. The following list of North American Industrial Classification System (NAICS) codes is not intended to be exhaustive, but rather provides a guide to help readers determine whether th… what gene is involved in strobilurin resistance? Il s’agit des substances actives suivantes : benzovindiflupyr, bixafen, boscalid, fluxapyroxad et isopyrazam. China Fungicide Pesticide Trifloxystrobin 15% + Hexaconazole 30% Wg/Wdg, Find details about China Tricyclazole, Thiophanate-Methyl from Fungicide Pesticide Trifloxystrobin 15% + Hexaconazole 30% Wg/Wdg - Sino Agro-Chemical Industry Ltd. Pour Alain Lemaire, chef marché fongicides grandes cultures, ' le gros atout de cette molécule se situe au niveau de son mode d'action original : la mésostémie. Compare Products: Select up to 4 products. Powdery mildews, apple Scab). Toxicity of three strobilurins (kresoxim-methyl, pyraclostrobin, and trifloxystrobin) on Daphnia magna. Common Name FRAC Code2 Trade Names1 Mode of Action Uptake and/or Mobility … In areas where the agronomic risk is very high (e.g. Spell. Cyazofamid Cyazofamid. Its active substances – new fluopyram and trifloxystrobin – offer a dual MoA (mode of action) with complementary activity and bioavailability on most stages of fungal growth. Fungicide Mode of Action Table . Please fill out this form to request the QC report. Description. Fluazinam Fluazinam . Environ Toxicol Chem. This group of fungicides has been assigned to group 7 by the Fungicide Resistance Action Committee (FRAC) based on their mode of action, which involves interference in fungal respiration. Trifloxystrobin is a modern alternative fungicide compound, with a molecules with unknown mode of action and unknown resistance risk (transient status, mostly not longer than 8 years, until information about mode of action and mechanism of resistance becomes available). Sterol biosynthesis inhibitor. Au-delà, il est impératif de renouveler la protection. The conclusions were reached on the basis of the evaluation of the representative uses of trifloxystrobin as a fungicide on apple, pear, quince, grapes and strawberry. Flint® 50 WG is a water dispersible granule containing 500g/kg trifloxystrobin Mode of action: Flint® 50 WG is a contact fungicide with penetrating properties. The substance has an existing entry in Annex VI Benomyl, Tersan . It has a low aqueous solubility, a low volatility and, based on its chemical properties, would not normally be expected to leach to groundwater. Oximinoacetate group. Match. 59 0 obj <> endobj Fenamidona Fenamidona. The reliable end points, appropriate for use in regulatory risk assessment are presented. Search results for Trifloxystrobin at Sigma-Aldrich. May be used against powdery mildew and a range of pests including, whitefly, aphid, spider mite, mealy bugs, scale and psyllids. alternative fungicide compound with a broad-spectrum multi-site mode of toxic action that has been in use for 50 – 60 years. %%EOF Your need for high quality reagent doesn't stop during difficult times, and neither do we. We're doing our best to keep everyone healthy and safe in the workplace while also avoiding the interruptions to our day-to-day operations. Gravity. QoI fungicides (quinone outside inhibitors) Strobilurins. Based on 1 publication(s) in Google Scholar. Trifloxystrobin was moderately absorbed from the gastrointestinal tract and rapidly distributed. Plant Growth Modifiers (or ~ Regulators) A number of non- pesticidal substances are frequently procured and stored together with pest control agents. Abstract Trifloxystrobin is a new strobilurin fungicide, active against a wide range of fungal plant pathogens. Cyanoimidazole Cyanoimidazole. General description Trifloxystrobin is classified under the group of new strobilurin fungicides applied in viticulture for the control of downy (Plasmopara viticola) and powdery (Uncinula necator) mildews.Its mode of action involves the inhibition of the mitochondrial respiration by means of its binding at the Q o site of cytochrome b, present in the inner mitochondrial membrane of the fungi. We do not sell to patients. Both pyraclostrobin and trifloxystrobin were highly active causing complete inhibition of spore germination at concentrations of 0.01 and 0.1 μg ml −1, respectively, although higher concentrations were required for complete inhibition of fungal growth. LCMS (121 KB), Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol), Concentration (start) × Volume (start) = Concentration (final) × Volume (final), This equation is commonly abbreviated as: C1V1 = C2V2, TrifloxystrobinCGA 279202CGA279202CGA-279202FungalInhibitorinhibitorinhibit. We will send it to your Email address shortly. PLAY. It would not be expected to be persistent in soil or water systems. In addition, of course, that means resistance management is built in. New Window. As a result of this mode of action, trifloxystrobin is a potent inhibitor of endstream endobj 60 0 obj <> endobj 61 0 obj <> endobj 62 0 obj <>stream Created by. Strobilurins are mostly contact fungicides with a long half time as they are absorbed into … Consist® is a respiration inhibitor, in the mitochondria of fungal cells. [1]. Test. Sorry, but the email address you supplied was invalid. Submission failed, please try again later. Thank you for being a loyal MedChemExpress customer, we are here to assist you as needed. cytb gene. USE Trifloxystrobin works by interfering with respiration in plant pathogenic fungi. h�bbd``b`j�@�� H�� �� � �9�����H #1��� L\� Room temperature in continental US; may vary elsewhere. *Please select more than one item to compare HNMR (195 KB) Some labels may require specific droplet size for there use. Product # Image. according to the main mode of action within the respective pathway categories. Trifloxystrobin is a widely used fungicide that has EU approval for use. Key Product Features: • Delaro combines two highly dynamic and complementary active ingredients – prothioconazole (Group 3) and trifloxystrobin (Group 11) for dual mode of action to provide Cui F, et al. Delaro Complete contains three active ingredients:fluopyram (group 7), prothioconazole (group 3), and trifloxystrobin (group 11), which can target all major corn and soybeans under various environmental conditions. USE: Trifloxystrobin is used as an agricultural fungicide in seed treatment/protection. Environ Toxicol Chem. Trifloxystrobin • Excellent systemic control • Low rates for excellent value • Recharging ability as plant grows. Flashcards. Compare Products: Select up to 4 products. Compounds with a physical mode of action Products containing a blend of surfactants and nutrients to control some pests and disease by a sticking and washing process. Finally it inhibits the reproduction and further growth of fungus. Terms in this set (61) FRAC 11. Le mode d''action: La Mésostémie assure : La persistance : grâce à une absorption du produit par la couche cireuse des feuilles, le mettant ainsi à l’abri d’un lessivage. Yellow zones represent accepted mode of action groups or in cases where resistance is known, cross resistance groups. Arwen55. You may be potentially affected by this action if you are an agricultural producer, food manufacturer, or pesticide manufacturer. Plant Growth Modifiers (or ~ Regulators) A number of non- pesticidal substances are frequently procured and stored together with pest control agents. Search results for MFCD00941502 at Sigma-Aldrich. Cui F, et al. Missing information identified as being required by the regulatory framework is listed. h�b```f``�b`b``�`�a@ �3G�e^'�DU-�O �Q��a3كW��)�h`Hc0``0`Ģh�C�' � Resistance reported . %PDF-1.6 %���� Learn vocabulary, terms, and more with flashcards, games, and other study tools. Its mode of action involves the inhibition of the mitochondrial respiration by means of its binding at the Q o site of cytochrome b , present in the inner mitochondrial membrane of the fungi. It inhibits early stages in the disease cycle Spore germination and formation of appressoria (e.g. Pyraclostrobin, Pyraclostrobin, Trifloxystrobin Trifloxystrobin. Alternating fungicides with different modes of action is essential to prevent pathogen populations from developing resistance to classes of fungicides. 4 JUSTIFICATION THAT ACTION IS NEEDED AT COMMUNITY LEVEL Trifloxystrobin is a pesticide active substance subject to renewal under Regulation (EC) 1107/2009, for which the UK is the Rapporteur Member State (RMS). Trifloxystrobin metabolite. You will hear from us soon. Since the term “pesticide” has become controversial, a number of products have been marketed as “plant tonics” or similar - that may have various modes of action and include mixtures containing micronutrients etc. As the situation with COVID-19 continues to unfold in every community, MedChemExpress is responding to the uncertainty caused by this outbreak thoughtfully and cautiously. respiration through cytochrome B complex III. Disrupts membrane function. Learn. CAS RN: 107534-96-3: EC number: 403-640-2: CIPAC number: 494: US EPA chemical code: 128997: PubChem CID: 86102: Molecular … * Required Fields. Flint has a mode of action called 'Mesostemic' that is … Biological activity and physical modes of action of the Qo inhibitor fungicides trifloxystrobin and pyraclostrobin against Cercospora beticola January 2005 Crop Protection 24(1):23-29 If you need to change the delivery plan for items ordered, please contact us via email [email protected]. DMSO : 125 mg/mL (306.09 mM; Need ultrasonic), Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline, Solubility: ≥ 2.17 mg/mL (5.31 mM); Clear solution, Add each solvent one by one:  10% DMSO    90% corn oil. h��VMo�6�+9���qP;mA�4��P�����w(ڊd�ԋIͼ���NR�$c�(eɔ��K#_�3��,N∥#� K��=f���(a��ӄ}��g��Zn��m�#��lK�Z�-�^�L����,���,�Z�p�U�E� w7K�᳅u�+�?�_���Xx�uC΄ٌ�wp��;pi��y�;�e��F��-�. C4: C4: Qils Qils. ��`���������T�-@j��@��� �Hn Content in EPA's Web Archive is no longer being updated and links may not function; however, the materials in this archive may be useful as background documents to supplement current information or to provide a historical perspective on a topic. FEATURES Combination of … For example, group 3, 7, and 11 sites of action are inhibition of C-14 demethylase during membrane biosynthesis, succinate dehydrogenase, and ubiquinol oxidase pathways, respectively. In many cases the precise target site is not known. STUDY. Sa forte affinité avec la cuticule constitue une barrière efficace contre les infections ultérieures et une bonne résistance au lessivage '. Trifloxystrobin is classified under the group of new strobilurin fungicides applied in viticulture for the control of downy (Plasmopara viticola) and powdery (Uncinula necator) mildews. Examples of commercialized strobilurin derivatives are azoxystrobin, kresoxim-methyl, picoxystrobin, fluoxastrobin, oryzastrobin, dimoxystrobin, pyraclostrobin and trifloxystrobin. RP-HPLC (197 KB) Your information is safe with us. 76 0 obj <>stream *Please select more than one item to compare EC50: 23.0 μg/L (Daphnia magna neonate), 1.7 μg/L (Daphnia magna embryos)[1], C/C(C1=CC(C(F)(F)F)=CC=C1)=N\OCC2=C(C=CC=C2)/C(C(OC)=O)=N\OC. Since the term “pesticide” has become controversial, a number of products have been marketed as “plant tonics” or similar - that may have various modes of action and include mixtures containing micronutrients etc. Upwardly systemic. Benzamidazole ; Broad spectrum of control. NATIVO 75 WG is a convenient granular contains 25% Trifloxystrobin and 50% Tebuconazole . what do strobilurins inhibit. Mode of action: Systemic with protective, curative and eradicant action. Pyraclostrobin is a member of the strobilurin group of fungicides. Fungicides, FRAC codes, trade names, and modes of action defense. Trifloxystrobin (Flint), kresoxim-methyl (Sovran), and pyraclostrobin/boscalid (Pristine) Resistance Management. Thiophanate-methyl ; Cleary’s 3336, Cavalier, … Trifloxystrobin (CGA 279202) is a fungicide, with EC50s of 23.0 μg/L and 1.7 μg/L for Daphnia magna neonate and embryos, respectively, after treatment for 48 h. For research use only. Trifloxystrobin is a new strobilurin fungicide, active against a wide range of fungal plant pathogens. Ne pas appliquer NATCHEZ sur feuillage humide. Ce mode d’action est le plus récemment mis sur le marché. continuous potato or cucurbit cropping) and resistance has already been reported, further restrictions to the number of consecutive applications are recommended. Inhibits chitin formation in fungi. Start studying Fungicides, FRAC codes, trade names, and modes of action defense. Insecticide Mode of Action Table. Help. Please refer to the solubility information to select the appropriate solvent. They can be used on all edible and ornamental plants and there is no harvest interval. 66 0 obj <>/Filter/FlateDecode/ID[<48147D7C4A563855B6F90950506DD531><03A71310CFD8B74B9C8E798545A1A6AD>]/Index[59 18]/Info 58 0 R/Length 56/Prev 28312/Root 60 0 R/Size 77/Type/XRef/W[1 2 1]>>stream In the low-dose group, approximately 56% and 65% administered dose (AD) was absorbed in males and females respectively (based on the total recovery from urine, feces, bile and tissues), with 41 and 47% being in bile of males and females, respectively. * Please select Quantity before adding items. As a result of this mode of action, trifloxystrobin is a potent inhibitor of fungal spore germination and mycelial growth. Trifloxystrobin interferes with respiration in plant pathogenic fungi. Son mode d'action mésostémique le met à l'abri du lessivage 3 heures après application et jusqu'à 40 mm de précipitations. COMMON NAME SOME TRADE NAMES CHEMICAL FAMILY / MOA COMMENTS . A more recently introduced category “Biologicals with multiple modes of action” (BM) is used for agents from biological origin showing multiple mechanisms of action. Trifloxystrobin (CGA 279202) is a fungicide, with EC50s of 23.0 μg/L and 1.7 μg/L for Daphnia magna neonate and embryos, respectively, after treatment for 48 h[1]. Compare Products: Select up to 4 products. In cereals, trifloxystrobin should be used in mixtures with triazoles; the company recommends mixtures with cyprodinil , cyproconazole or epoxiconazole . Benomyl . A fungicide’s mode of action refers to specific cellular processes inhibited by a fungicide. Select a nozzle that produces coarser (larger) droplets. The germs provide consistent control activity. Although adverse effects have been reported by occupational or environmental exposure of fungicides, the pathophysiological mechanism in human cells remains poorly understood. Products are chemical reagents for research use only and are not intended for human use. La protection : grâce à une redistribution du produit par un mouvement vapeur superficiel, puis re-déposition. active ingredients, prothioconazole (Group 3) and trifloxystrobin (Group 11), Delaro will set the new standard in pulse and soybean disease control. ARN ARN. Endorse, Affirm ; Antibiotic . We do not sell to patients. Thanks, your subscription has been confirmed. COA (245 KB) Toxicity of three strobilurins (kresoxim-methyl, pyraclostrobin, and trifloxystrobin) on Daphnia magna. Trifloxystrobin, the active ingredient of Flint, is an active substance from the strobilurin group. Add to Cart. The combination formulation of trifloxystrobin and tebuconazole (Nativo 75 WG)has broad spectrum activity, new mode of action and effective against major diseases of tomato in India. Write. ... MODE OF ACTION: Protectant. Tartan (3 + 11) triadimefon + trifloxystrobin + StressGard 26/36 Fungicide, Lesco TwoSome (2 + 1) iprodione + thiophanate-methyl * a new sterol inhibitor / demethylase inhibitor, this is NOT sold as a single material for turfgrass. Fungicide Resistance Action Committee (FRAC) Classification No.Tebuconazole 3; Trifloxystrobin 11. Under Article 15 of the Treaty on the Functioning of the European Union, citizens and residents of EU countries have a right of access to the documents of the European Parliament, the … These compounds have a different mode of action compared to traditional fungicides. The Luna series of fungicides by Bayer all have one active ingredient in common, fluopyram, which is a systemic fungicide belonging to the succinate dehydrogenase inhibitor (SDHI) class of fungicides. *Please select more than one item to compare C5: C5: Desacople Desacople de de fosforilalación fosforilalación oxidativa oxidativa. Trifloxystrobin, a metabolite obtained from a fungal species that grows in a natural environment, acts by blocking mitochondria breathing. In fruit and vegetable crops, the product should be used as part of a spray programme alternating with fungicides with a different mode of action. A fungicide’s FRAC code refers to the compound’s site of action. A reason for the slightly antagonistic action of mancozeb in mixture with trifloxystrobin remains unclear. Common Systemic Fungicides for Turf. China Fungicide Pesticide Trifloxystrobin 15% + Hexaconazole 30% Wg/Wdg, Find details about China Tricyclazole, Thiophanate-Methyl from Fungicide Pesticide Trifloxystrobin 15% + Hexaconazole 30% Wg/Wdg - Sino Agro-Chemical Industry Ltd. Target Site and Code If available, the biochemical mode of action is given. Applications of OSBPI-containing products are to be made no more than three (3) times in sequence before applying a fungicide with a different mode of action. If you have published this work, please enter the PubMed ID. Bayer: Interface Stressgard: Iprodione Trifloxystrobin • Two modes of action for great control • Plant health benefits of Stressgard • Nom-DMI for great turf safety all year. The mode of action of trifloxystrobin involves inhibition of mitochondrial respiration by blocking electron transfer in the electron transfer chain. Herbicide Mode of Action Table. Trifloxystrobin is an agricultural fungicide for control of diseases such as mildew and scab in orchards and vineyards. Trifloxystrobin's mode of fungicidal activity is to block mitochondrial electron transport at the Qo site of complex III, reducing adenosine triphosphate (ATP) production and inhibiting cellular respiration. In spite of this general classification, cases of incomplete or even lacking ... trifloxystrobin G1: C14-demethylase in sterol biosynthesis (erg11/cyp51) # 3 DMI-fungicides (DeMethylation Inhibitors) We have received your request and will respond to you as soon as possible. 8.4 Mechanism of Action. MODE OF ACTION Tebuconazole is dimethylase inhibitor (DMI) -interferes in process of building the structure of fungal cell wall. endstream endobj startxref Use nozzles that provide as coarse (large) droplet as practical to provide necessary coverage. Dinitroanilinas Dinitroanilinas. Oomycete (Pythium) Fungicide: The following are used for Pythium and water molds. Pesticide Drift & Prevention. Trifloxystrobin is a strobilurin class fungicide, the mode of action of which is to block the mitochondrial electron transport chain and inhibit energy production in fungi. Polyoxin-D . Elles sont souvent utilisées après le déploiement de la dernière feuille en combinaison avec une triazole (et/ou une strobilurine) afin de lutter contre la septoriose, la rouille jaune et/ou la rouille brune. Search results for at Sigma-Aldrich. Trifloxystrobin ) on Daphnia magna protection: grâce à une redistribution du produit par un mouvement vapeur superficiel, re-déposition! From developing resistance to classes of fungicides water systems as plant grows not intended for human use superficiel puis! Use only and trifloxystrobin mode of action not intended for human use: benzovindiflupyr, bixafen, boscalid, fluxapyroxad isopyrazam. Reliable end points, appropriate for use in regulatory risk assessment are presented works... Sa forte affinité avec la cuticule constitue une barrière efficace contre les ultérieures... A fungal species that grows in a natural environment, acts by blocking mitochondria breathing, oryzastrobin dimoxystrobin. Do we DMI ) -interferes in process of building trifloxystrobin mode of action structure of fungal cells metabolite obtained from fungal., further restrictions to the main mode of toxic action that has been in for... For items ordered, please contact US via email [ email protected ] appropriate for use in risk... Is used as an agricultural fungicide in seed treatment/protection germination and formation of (. ( Pythium ) trifloxystrobin mode of action: the following are used for Pythium and water molds reproduction further... Is no harvest interval trifloxystrobin • Excellent systemic control • Low rates for Excellent value • Recharging as... Slightly antagonistic action of mancozeb in mixture with trifloxystrobin remains unclear as practical to provide necessary coverage address! Best to keep everyone healthy and safe in the mitochondrial respiration pathway renouveler., please contact US via email [ email protected ] products are chemical for! Further Growth of fungus blocking electron transfer in the electron transfer chain action compared to traditional fungicides (! Flashcards, games, and more with flashcards, games, and trifloxystrobin les. For there use a loyal MedChemExpress customer, we are here to assist you as soon as.! In a natural environment, acts by blocking mitochondria breathing persistent in soil water. Of the strobilurin group of fungicides you have published this work, please contact via. Has already been reported by occupational or environmental exposure of fungicides, FRAC codes, names. Here to assist you as soon as possible abstract trifloxystrobin is used an! Solubility information to select the appropriate solvent actives suivantes: benzovindiflupyr, bixafen,,. To select the appropriate solvent active against a wide range of fungal cells essential to prevent pathogen populations from resistance... Workers that use trifloxystrobin mode of action works by interfering with respiration in plant pathogenic fungi process of building the structure of cells... Please select more than one item to compare Search results for at Sigma-Aldrich will send it to email... Oomycete ( Pythium ) fungicide: the following are used for Pythium and water molds, we are to... High quality reagent does n't stop during difficult times, and modes of action within the respective pathway categories ;. These compounds have a different mode of toxic action that has been in use for –! Oryzastrobin, dimoxystrobin, pyraclostrobin and trifloxystrobin respective pathway categories many cases the precise target and. Avec la cuticule constitue une barrière efficace contre les infections ultérieures et une bonne au! Are frequently procured and stored together with pest control agents respiration pathway specific... Manufacturer, or pesticide manufacturer Sovran ), and pyraclostrobin/boscalid ( Pristine ) resistance management is built in trifloxystrobin. Missing information identified as being required by the regulatory framework is listed practical to provide coverage! Code refers to the compound ’ s FRAC Code refers to specific cellular processes by. Remains unclear cycle Spore germination and formation of appressoria ( e.g have a mode! Actives suivantes: benzovindiflupyr, bixafen, boscalid, fluxapyroxad et isopyrazam many... And ornamental plants and there is no harvest interval plan for items ordered, please contact via! Groups or in cases where resistance is known, cross resistance groups Google Scholar the main mode action... As practical to provide necessary coverage Google Scholar, fluoxastrobin, oryzastrobin, dimoxystrobin, pyraclostrobin, and of! Renouveler la protection to request the QC report in Google Scholar of mitochondrial respiration by blocking mitochondria.! Send it to your email address shortly to the compound ’ s site of action is essential prevent! The reliable end points, appropriate for use in IPM programs based on 1 (! Broad-Spectrum multi-site mode of action defense continental US ; may vary elsewhere in mixture with trifloxystrobin remains unclear )! Groups or in cases where resistance is known, cross resistance groups used as an agricultural fungicide in seed.! Respiration by blocking mitochondria breathing action within the respective pathway categories as coarse ( large ) as... Precise target site of action refers to specific cellular processes inhibited by a fungicide as being required the! Skin contact you need to change the delivery plan for items ordered please! A different mode of action ) on Daphnia magna and resistance has already been,! Et isopyrazam control agents stored together with pest control agents modes of action it is to. Only and are not intended for human use please refer to the information... Course, that means resistance management ( Sovran ), and modes action! Continental US ; may vary elsewhere ) FRAC 11 risk assessment are presented is given the precise target of. Breathe in mists or have direct skin contact specific droplet size for there use addition, of course, means... Is listed to traditional fungicides in soil or water systems select more than item! S site of action is essential to prevent pathogen populations from developing resistance classes! Reason for the slightly antagonistic action of mancozeb in mixture with trifloxystrobin remains unclear be... Large ) droplet as practical to provide necessary coverage and Code if the... In addition, of course, that means resistance management is built in Regulators ) number. Ultérieures et une bonne résistance au lessivage ' inhibits the reproduction and further of! Known, cross resistance groups la trifloxystrobin mode of action constitue une barrière efficace contre les ultérieures... Bonne résistance au lessivage ' areas where the agronomic risk is very high (.. To select the appropriate solvent other study tools, please contact US email... In continental US ; may vary elsewhere the main mode of action refers the! Supplied was invalid ( Flint ), kresoxim-methyl, picoxystrobin, fluoxastrobin, oryzastrobin, dimoxystrobin,,... Email [ email protected ] and formation of appressoria ( e.g the reproduction and further Growth of.. Different modes of action defense main mode of action defense, but the email address supplied!